Police are attending a serious collision on the bends between the Cohannon Inn and the Moor Road, near Tamnamore Roundabout, this morning (Wednesday).
The Ballynakilly Road has been closed between the roundabout at Junction 14 and Moor Road.
There are now a number of major diversions in place in the district, and police have asked motorists not to attempt to bypass these and/or enter the scenes.
Meanwhile, the Cookstown Road in Dungannon is closed in both directions between the Tullycullion Road and Coal Pit Road due to a collision.
Diversions are in place and motorists are advised to avoid the area.