The incident happened around 9pm near the Derryhale Road junction, close to Chapman’s Farm.
One eye-witness has told Armagh I that there could be at least four vehicles, including a lorry, involved in the collision.
However, these are unconfirmed reports at this stage.
Traffic is backed up in both directions with motorists being turned around by police.
Emergency services are currently working at the scene at the moment.
Motorists are advised to avoid this area tonight.
There are no further details at this stage. Updates to follow…